A-PRF™ | Advanced Platelet Rich Fibrin
Chairside access to the patients healing potential from venous blood
The concept of PRF (Platelet Rich Fibrin) is based on the centrifugation of whole blood without anticoagulants. (J. Choukroun et al. 2001). At the end of the spin, a fibrin clot containing the majority of the platelets and white blood cells is obtained.
This fibrin clot called Platelet Riche Fibrin or PRF will release gradually growth factors or cytokines in the site (VEGF, PDGF, TGF Beta, Thrombospondin)
The expected objective of these growth factors is to accelerate the soft tissue and bone healing.
Numerous international publications are available and demonstrate the effectiveness of PRF in many indications: oral surgery (implants, bone grafting, periodontal surgery, extractions, etc…), Orthoepedic, cosmetic and dermatological surgery.
A-PRF™ fibrin membrans for stimulation of the inflammatory cascade and faster healing
A-PRF™ | The process & application
A-PRF | membrane on wound after 1 week
The same A-PRF™ membranes as on the left picture – now one week later.
See more about wound healing here
A-PRF™ Clots in box
A-PRF™ | Videos
A-PRF | intro to PRF box
Short introduction creation of A-PRF™ membranes using the PRF box.
A-PRF | bone graft created from membranes and bonematerials
Bone particles mixed with A-PRF™ membrane cut into pieces formed into a graft. i-PRF™ is then injected onto the graft and it clots
A-PRF | sandwich graft
Combination of A-PRF™ and i-PRF™ in creating bone grafts from bone substituts.
DUO Centrifuge solution
A-PRF™ | Team and litteratur
Dr. Joseph Choukroun
received his diploma in 1979 in Montpellier, France. Specialist in anesthesiology in 1981, University of Montpellier. Fellowship of Pain Clinic, University of Strasbourg. Chief of staff of the Private Pain Clinic, Nice. President and creator of the SYFAC, international symposium on growth factors, Nice.
Inventor of the PRF technique. Author on several scientific and clinical papers for scientific journals. International Speaker.
Dr. Joseph Choukroun is pushing the research on PRF together with scientists from the Laboratory of Clarion Research Group, Pennsylvania University (USA) and Repair-Lab, Institute of Pathology, Johannes Gutenberg University, Mainz (Germany) and Physicians around the world.
with membranes ready to use – notice the instruments made for handling the membranes
A-PRF™ | Advantages of PRF over PRP
- No biochemical handling of blood.
- Simplified and cost-effective process.
- Use of bovine thrombin and anticoagulants not required.
- Favorable healing due to slow polymerization.
- More efficient cell migration and proliferation.
- PRF has supportive effect on immune system.
- PRF helps in hemostasis.
- Release of growth factors for more than 10 days
- Higher overall growth factor release than PRP
Source: Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan Ehrenfest DM. Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent. 2009;1:21–30.
A-PRF™ | Literature
- Publication overview 2001 – 2016, (include pubmed links)
- The Low Speed Concept
- Classification of platelet concentrates..
- Comparative release of growth factors from PRP, PRF, and advanced-PRF.
- PRF a second gen – part 1.pdf
- PRF a second gen – part 2.pdf
- PRF a second gen – part 3.pdf
- PRF a second gen – part 4.pdf
- PRF a second gen – part 5.pdf